What is Drug-Drug and Drug-Food Interaction ?

What is Drug-Drug and Drug-Food Interaction ?

What is Drug-Drug and Drug-Food Interaction?

A drug interaction is a reaction between two (or more) drugs(drug and drug) or between a drug and food, beverage, or supplement. Taking a drug while having certain medical conditions can also cause a drug interaction. For example, taking a nasal decongestant if you have high blood pressure may cause an unwanted reaction. A drug interaction can affect how a drug works or cause unwanted side effects. let’s know about what is drug-drug and drug-food interaction?

A drug-food interaction occurs when your food and medicine interfere with one another. Interactions can happen with both prescription and over-the-counter medicines. These include antacids, vitamins, and iron pills.

Not all medicines are affected by food. Some, though, are affected by what you eat or when you eat it. Taking medicine at the same time you eat can cause your body not to absorb the medicine. Or certain foods may delay or decrease the absorption of the drug. For example, you should not combine dairy and antibiotics. This is why some medicines should be taken on an empty stomach (1 hour before eating or 2 hours after eating).

Some medicines cannot be taken with certain types of food. The food can cause a reaction that changes the effect of the medicine. It also can create or heighten side effects. An example of this is having grapefruit or grapefruit juice with cholesterol drugs. If you take an ACE inhibitor, you should avoid foods high in potassium, such as bananas.


What is drug interaction?

Medicines help us feel better and stay healthy. But sometimes drug interactions can cause problems. There are three types of drug interactions:

Drug-drug interaction: A reaction between two (or more) drugs.
Drug-food interaction: A reaction between a drug and a food or beverage.
Drug-condition interaction: A reaction that occurs when taking a drug while having a certain medical condition. For example, taking a nasal decongestant if you have high blood pressure may cause an unwanted reaction.

A drug interaction can affect how a drug works or cause unwanted side effects.

Why are some drugs taken before meals?

Some medicines need to be taken “before food” or “on an empty stomach”. This is because food and some drinks can affect the way these medicines work. For example, taking some medicines at the same time as eating may prevent your stomach and intestines from absorbing the medicine, making it less effective.

Take some drugs before meals

Some medications should be taken on an empty stomach. This is usually because food prevents the medication from being fully absorbed into the body.

Medications that should be taken on an empty stomach include:

  • ampicillin
  • bisacodyl
  • cloxacillin
  • didanosine
  • etidronate
  • risedronate
  • sotalol
  • sucralfate
  • tetracycline
  • zafirlukast

A recent study in Washington found that only 67% of serious drug interactions resulted in a correct warning from a pharmacy computer system designed to warn of significant drug interactions. Causes contributing to a harmful drug? Do drug interactions include narrow therapeutic dosage ranges associated with certain drugs and a patient?s disease state. For example, patients with epilepsy have increased chances of drug interaction, compared with those with other disease states.

Some Example of Drug and Drug interaction –

  • Fluoxetine and Phenelzine.
  • Digoxin and Quinidine.
  • Sildenafil and Isosorbide Mononitrate.
  • Potassium Chloride and Spironolactone.
  • Clonidine and Propranolol.
  • Warfarin and Diflunisal.
  • Theophylline and Ciprofloxacin.
  • Pimozide and Ketoconazole
  • Methotrexate and Probenecid
  • Bromocriptine and Pseudoephedrine

Role of Pharmacist

The mission of pharmacy practice as a Pharmacist is to help patients make the best use of their medication. This means providing safe, effective, timely, and cost-conscious therapy. From the safety viewpoint, the pharmacist has the legal duty to warn about potentially harmful drug interactions. The warning should be directed to the prescribing physician in a manner that will increase the chances of avoiding drug interaction.

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